Wednesday, May 07, 2014

D-ribose in pregnancy

I've been studying the effects of d-ribose on pregnancy this week, curious if it's safe to take d-ribose when you're pregnant.

So far, the usual forums, doctor-moderated boards, and public health sites have been of zero help. So I turned to Google Scholar.

What I learned, from reading scientific papers, is that, at least in mice, high doses (like 158 grams a day for a human; the usual therapeutic dose for a human is 15 grams a day) of ribose delivered intravenously causes dementia and is highly toxic to cells. (The regular human therapeutic dose was studied, too, and had no ill effects). So don't overdose. (

But I also learned that, at least in rats, dietary ribose supplementation, even in extremely high doses (up to 789 grams per day for a human) has absolutely zero affect on pregnancy or babies. The babies, placentas, etc, were physically indistinguishable from the control group.  (

That would indicate that ribose is safe for pregnancy, at least for rats.

It does cross the blood-brain barrier, and enters cells through diffusion, so there is a good chance that it would cross the placental barrier as well, though.  And, since ribose is unsafe for diabetics, I imagine it would be unsafe for those with gestational diabetes as well.  Also, there was no research regarding the mental development of the rats.

Someone has also submitted a patent to use ribose to treat newborn stroke.  This doesn't prove it's safe of course (lots of wacky patents are submitted), but at least one scientist thinks it is.

No comments: